BACKGROUND:To evaluate the contribution of chemotherapy for patients with locoregionally advanced nasopharyngeal carcinoma (NPC) treated by intensity modulated radiotherapy (IMRT) and to identify the optimal combination treatment strategy.PATIENTS AND METHODS:Between 2006 and 2010, 276 patients with stage II-IVb NPC were treated by IMRT alone or IMRT plus chemotherapy.Cisplatin-based chemotherapy included neoadjuvant SCREEN FRAME CORNERS or concurrent, or neoadjuvant plus concurrent protocols.The IMRT alone and chemoradiotherapy groups were well-matched for prognostic factors, except N stage, with more advanced NPC in the chemoradiotherapy arm.
RESULTS:With a mean follow-up of 33.8 months, the 3-year actuarial rates of overall survival (OS), metastasis-free survival (MFS), relapse-free survival (RFS), and disease-free survival (DFS) were 90.3%, 84.2%, 80.
3%, and 69.2% for all of the patients, respectively.Compared with the IMRT alone arm, patients treated by concurrent chemoradiotherapy had a significantly better DFS (HR = 2.64; 95% CI, 1.
12-6.22; P = 0.03), patients with neoadjuvant-concurrent chemoradiotherapy had a significant improvement in RFS and DFS (HR = 4.03; 95% CI, 1.
35-12.05; P = 0.01 and HR = 2.43; 95% CI, 1.
09-5.44; P = 0.03), neoadjuvant chemoradiotherapy provided no significant benefit in OS, MFS, RFS, and DFS.Stage group and alcohol consumption were prognostic factors for OS and N stage was a significant predictor for DFS.
CONCLUSIONS:Addition of concurrent or neoadjuvant-concurrent chemotherapy to IMRT Edibles is available to prolong RFS or DFS for locoregionally advanced NPC.Such work could be helpful to guide effective individualized therapy.